MT-1 10mg (Afamelanotide)

MT-1 10mg Research Peptide UK (Afamelanotide)

MT-1 10mg (Melanotan I, Afamelanotide) is a synthetic analogue of alpha-melanocyte stimulating hormone (alpha-MSH). It is a selective agonist at the melanocortin-1 receptor (MC1R) with documented minimal activity at MC3R, MC4R, and MC5R. As an mt1 10mg research peptide, it is the most receptor-selective compound in the Melanotan Research Peptide category and the appropriate tool for isolated MC1R biology research.

MC1R is expressed on melanocytes, keratinocytes, immune cells, and multiple other tissue types. In laboratory research models, MC1R activation by MT-1 initiates intracellular cAMP signalling, leading to MITF (microphthalmia-associated transcription factor) activation and downstream melanogenesis pathway regulation. Published preclinical literature documents MT-1 10mg in melanocyte differentiation research, UV response modelling, pigmentation biology assays, and immune cell MC1R pharmacology studies.

The critical experimental design question for selecting between the two Melanotan research peptides is receptor specificity. MT-1 10mg is the correct compound when research specifically requires isolated MC1R pathway investigation without simultaneous activation of MC3R, MC4R, and MC5R. MT-2 10mg activates all four melanocortin receptor subtypes simultaneously — making it appropriate for broad melanocortin system research but producing multi-receptor activation that complicates attribution to any single receptor subtype. For a complete side-by-side receptor selectivity comparison, see the MT-1 10mg research guide and MT-2 10mg research guide on the Ascend Peptides UK blog.

Regulatory note: Afamelanotide (the INN for MT-1) is approved under the brand name Scenesse by the EMA under assessment report EMA/CHMP/482080/2014 for a specific clinical indication. This clinical approval does not extend to the lyophilised research format supplied by Ascend Peptides UK, which is designated for in-vitro laboratory research only.

For researchers requiring both MT-1 and MT-2 for comparative melanocortin receptor studies, the MT-1 plus MT-2 Melanocortin Comparison Kit is available from Ascend Peptides UK.

All batches tested by Janoshik. HPLC greater than or equal to 98%. LC-MS confirmed. Verifiable CoA.

For laboratory handling purposes, MT-1 may be reconstituted using sterile aqueous solutions such as bacteriostatic water depending on experimental requirements.

WADA Status: Prohibited at all times.

DISCLAIMER: For in-vitro research only. Not an MHRA-licensed medicine.