MOTS-C 10mg

It is supplied by Ascend Peptides UK as a lyophilised powder in a single sealed vial, for laboratory research purposes only. The 10mg vial suits pilot investigations, method development and smaller experimental designs.

Most peptides studied in laboratories are encoded in the nuclear genome. MOTS-c belongs to a small group of mitochondrial-derived peptides, alongside humanin, that are encoded in mitochondrial DNA. It was identified in 2015 from a short open reading frame within the 12S rRNA gene; the name stands for mitochondrial open reading frame of the 12S rRNA type-c (Lee et al., 2015).

In the first published study, MOTS-c inhibited the folate cycle and de novo purine synthesis in cultured cells, leading to activation of AMPK, an energy-sensing enzyme; in mice, skeletal muscle appeared to be its main target tissue (Lee et al., 2015). A 2018 study reported that MOTS-c moves to the nucleus under metabolic stress, in an AMPK-dependent way, and regulates nuclear genes including those with antioxidant response elements (Kim et al., 2018).

These are cell and animal findings from the published literature. They are not properties tested on this product and do not describe any outcome in humans. A fuller explanation, including what is and is not known, is in What Is MOTS-C?

Both vials contain the same peptide. The 10mg vial suits pilot work and method development. The MOTS-C 40mg vial suits larger designs that need more material from one vial and one batch, and it is the format with a published Janoshik certificate.

No certificate of analysis has been published for the MOTS-C 10mg format yet. The published Janoshik report for MOTS-C 40mg (#125392) applies to that format and the batch named on it; it does not verify 10mg vials. Ascend publishes Janoshik certificates on the CoA page as they are returned.

The identifiers above (sequence, formula, molecular weight, CAS, UNII, PubChem and UniProt numbers) are reference values for the MOTS-c peptide from PubChem, the NCATS substance registry and UniProt. They describe the compound, not test results for a particular vial, and they refer to the free peptide; the salt form supplied has not yet been confirmed by the manufacturer.

Storage requirements for this product are being verified with the manufacturer. Please contact ASCEND before purchasing for information about the current product batch.

• Lee C, Zeng J, Drew BG, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015;21(3):443–454. PubMed 25738459
• Kim KH, Son JM, Benayoun BA, Lee C. The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress. Cell Metab. 2018;28(3):516–524.e7. PubMed 29983246
• Mitochondria-derived peptide MOTS-c substance record, UNII A5CV6JFB78: sequence and formula C101H152N28O22S2. NCATS Global Substance Registration System. GSRS A5CV6JFB78
• MOTS-c compound record, CID 146675088: molecular weight 2174.6 g/mol. PubChem. PubChem 146675088