GHK-Cu 50mg

GHK is the free tripeptide glycyl-L-histidyl-L-lysine (C14H24N6O4, CAS 49557-75-7, 340.4 g/mol). GHK-Cu is GHK bound to one copper(II) ion (C14H22CuN6O4, CAS 89030-95-5, 401.9 g/mol). In the complex, copper is held by the N-terminal amine of glycine, the adjacent amide nitrogen and the imidazole nitrogen of histidine (Hureau et al., 2011). The two are different research materials, so protocols should state which form they use. This vial contains the copper complex. A fuller explanation is in What Is GHK-Cu?

Published laboratory work has examined GHK-Cu in fibroblast culture, where it was reported to stimulate collagen synthesis from picomolar concentrations, with a maximum near 1 nM (Maquart et al., 1988). A review by Pickart and colleagues reports that GHK can up- or down-regulate at least 4,000 human genes; this is a gene-expression result, not an outcome study (Pickart et al., 2015). These are in-vitro findings about the compound in the literature. They are not properties tested on this product and do not describe any outcome in humans.

Research applications are covered in the GHK-Cu laboratory guide.

Both vials contain the same compound. The 50mg vial suits pilot investigations, method development and smaller experimental designs. The GHK-Cu 100mg vial suits programmes that need more material from a single vial and batch.

The chemical identifiers on this page (names, formula, molecular weight, CAS, UNII and PubChem numbers) are reference values for GHK-Cu from the NCATS GSRS record. They describe the compound, not test results for a particular vial.

No certificate of analysis has been published for the GHK-Cu 50mg format yet. Ascend publishes Janoshik certificates on the CoA page as they are returned. The published Janoshik report for GHK-Cu 100mg applies to that format and the batch named on it; it does not verify 50mg vials. How to check any certificate is explained on the batch verification page.

Storage requirements are currently being verified with the manufacturer. Please contact ASCEND before purchasing for information about the current product batch.

• Prezatide copper (copper tripeptide-1) substance record, UNII 6BJQ43T1I9: names, formula C14H22N6O4·Cu and molecular weight 401.91. NCATS Global Substance Registration System. GSRS 6BJQ43T1I9
• Hureau C, et al. X-ray and solution structures of Cu(II) GHK and Cu(II) DAHK complexes: influence on their redox properties. Chemistry. 2011;17(36):10151–60. PubMed 21780203
• Maquart FX, Pickart L, Laurent M, Gillery P, Monboisse JC, Borel JP. Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. FEBS Lett. 1988;238(2):343–6. PubMed 3169264
• Pickart L, Vasquez-Soltero JM, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. Biomed Res Int. 2015;2015:648108. PubMed 26236730